December 2012

Brain

Probabilistic Radiographic Atlas of Glioblastoma Phenotypes

Benjamin M. Ellingson

Investigators from our team recently discovered that patients with glioma having mutation of the isocitrate dehydrogenase-1 (IDH1) gene tended to have larger, nonenhancing tumors localized in the frontal lobe (Lai et al, J Clin Oncol, 2011; 29:4482-90). Using an approach similar to lesion-symptom mapping, we developed … more »

Brain

Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma

Leland S. Hu

MRI biomarkers have the potential to greatly impact glioma care.  However, the medical community has been slow to adopt these, in part, because we don’t yet fully understand their basic relationships with histologic correlates.

For instance, we have long assumed that pMRI measurements (ie, relative … more »