April 2013

Introduction

CT Perfusion in Nonsurgical Organ Preservation Therapy

Suresh Mukherji

Suresh Mukherji

CT perfusion provides the unique ability to noninvasively quantify the microvascular blood flow of tumors and normal tissues. CTP provides important information on the biologic response to nonsurgical organ preservation and has the potential to determine whether the tumor is properly responding to nonsurgical organ preservation therapy (NSOPT). The ability to noninvasively monitor tumor response during NSOPT is the “Holy Grail” … more »

Head & Neck

Perfusion CT in Squamous Cell Carcinoma

Sotirios Bisdas

Sotirios Bisdas

Malignancies in the head and neck and their nodal involvement often present in an advanced stage that reduces the chances for successful treatment and prolonged survival rates. Though clinical endoscopic examination is the cornerstone of therapeutic strategies, follow-up is hampered by unspecific tissue changes, whereas the response on the increasingly used neo-adjuvant therapy regimens is often inadequately assessed by conventional CT … more »

Head & Neck

Prediction of Locoregional Control in Head and Neck Squamous Cell Carcinoma with Serial CT Perfusion during Radiotherapy

Minh Tam Truong

Minh Tam Truong

Tumor perfusion and hypoxia have been of significant interest among head and neck radiation oncologists and radiologists, as it has been shown in radiobiologic studies that tumor hypoxia is a major determinant of radiation resistance in patients undergoing curative-intent radiotherapy for head and neck cancer. In our study we sought to define tumor perfusion parameters—including blood flow, blood volume, … more »

Head & Neck

Human Papillomavirus, p16, and Epidermal Growth Factor Receptor Biomarkers and CT Perfusion Values in Head and Neck Squamous Cell Carcinoma

Nickoleta L. Hoefling

Nickoleta L. Hoefling

While much of CTP application in neuroradiology has been in stroke and intracranial tumor imaging, previous interesting studies have shown CTP’s usefulness in head and neck cancer. It has been shown that CTP is not only useful in diagnosing head and neck cancer but also in predicting which tumors may respond better to nonsurgical organ preservation therapy.1 Changes in CTP … more »

Head & Neck

Correlation between Initial and Early Follow-Up CT Perfusion Parameters with Endoscopic Tumor Response in Patients with Advanced Squamous Cell Carcinomas of the Oropharynx Treated with Organ-Preservation Therapy

Dheeraj Gandhi

Dheeraj Gandhi

Recent advances in anatomic imaging techniques have significantly improved our ability to assess the locoregional spread of head and neck cancers. While CT and MR imaging remain the gold standard for radiographic evaluation in mapping the extent of primary tumor and regional metastasis, early and accurate detection of tumor recurrence, as well as assessment of response to induction chemotherapy, offer significant … more »

Head & Neck

Can Pretreatment CT Perfusion Predict Response of Advanced Squamous Cell Carcinoma of the Upper Aerodigestive Tract Treated with Induction Chemotherapy?

Aaron Zima

Aaron Zima

Traditional radiology has focused on the anatomic description of disease before and after therapy. While this is vital to the overall care of patients, as health care moves forward, there will be more and more emphasis placed upon cost containment and patient outcomes for administered therapies. Predicting whether a certain disease process will respond to a particular therapy will become increasingly … more »