December 2013

Introduction

Arterial Spin-Labeled MR Imaging in Neuroradiology

Joshua Nickerson

Joshua Nickerson

Brain perfusion imaging using MR is not a new idea, and indeed, both gadolinium-based techniques and noncontrast methods have been well described in the radiology literature for decades. However, in discussion with colleagues, both in academia and in the private practice world, it is apparent that, currently, dynamic perfusion scanning has become part of the routine clinical examination at only a … more »

Brain

Assessment of Vascular Supply of Hypervascular Extra-Axial Brain Tumors with 3T MR Regional Perfusion Imaging

Toshinori Hirai

Toshinori Hirai

We previously studied vascular supply of meningiomas with angio-CT. This experience led us to do new research work using MR regional perfusion imaging (RPI). When we applied RPI with selective labeling of the external carotid artery to a patient with meningioma, we happened to detect an interesting finding about vascular supply of the meningioma. From this experience, we thought that … more »

Brain

Arterial Spin-Labeling Assessment of Normalized Vascular Intratumoral Signal Intensity as a Predictor of Histologic Grade of Astrocytic Neoplasms

Julia Furtner

Julia Furtner

Arterial spin-labeling is an MRI technique that enables the quantitative determination of tissue blood flow values without the need to administer contrast agents, thus offering a noninvasive MRI perfusion sequence for the generation of cerebral perfusion maps. This method takes advantage of the fact that water protons of the arterial blood in the feeding vasculature of the brain are magnetically labeled … more »

Brain

Anoxic Injury-Associated Cerebral Hyperperfusion Identified with Arterial Spin-Labeled MR Imaging

Jeffrey M. Pollock

Jeffrey M. Pollock

I was fortunate to stumble into an ongoing research project by inadvertently ruining the first attempt at scanning a volunteer. I began my fellowship at Wake Forest in 2006 and took an interest in physiologic imaging of brain tumors, and I became interested in DTI, spectroscopy, and perfusion, beginning work on finding a gadolinium-based perfusion protocol to run on … more »

Review Article

Arterial Spin-Labeling in Routine Clinical Practice, Part 1: Technique and Artifacts

Joseph Maldjian

Joseph Maldjian

Arterial spin-labeling (ASL) perfusion MRI has been in development for over a decade.1–3 During much of this time it had remained predominantly a research tool. I was a neuroradiology fellow at the University of Pennsylvania when pioneering work in this area was being conducted by Drs. Detre and Alsop. They were developing the continuous arterial spin-labeling (CASL) methodology and extending it … more »

Brain

Migraine Associated Cerebral Hyperperfusion with Arterial Spin-Labeled MR Imaging

Jeffrey M. Pollock

Jeffrey M. Pollock

After joining the arterial spin-labeling (ASL) research team at Wake Forest, we began to mine our perfusion database. In addition to the global cases of hyperperfusion, we identified several causes of regional hyperperfusion without any other radiographic abnormality on MRI. Occasionally we thought these might be artifacts, but after reviewing the medical history more carefully, many of the cases … more »