March 2014

Introduction

Mild Traumatic Brain Injury

Saeed Fakhran

Saeed Fakhran

The imaging of mild traumatic brain injury (MTBI), commonly referred to as concussion, is a maturing and expanding field, with novel imaging methods being used for both clinical evaluation of patients as well as in research. While initial concussion imaging was focused on excluding more serious pathology (eg, hemorrhage) in these patients, the field has long since moved beyond this rather … more »

Functional

Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

Pratik Mukherjee

Pratik Mukherjee

Bruce McCandliss

Bruce McCandliss

DTI characterizes the microstructural properties of biologic tissues through measurements of the orientation-dependent diffusivity of water protons. This renders DTI particularly sensitive to human brain white matter pathology at microscopic spatial scales, because the longitudinal arrangement of the axolemma, microtubules, neurofilaments, and myelin sheaths along the direction of axonal fibers creates … more »

Brain

Proton MR Spectroscopy and MRI-Volumetry in Mild Traumatic Brain Injury

Oded Gonen

Oded Gonen

Traumatic brain injury (TBI) annually accounts for 1.6 million emergency department visits and hospitalizations in the United States.1 More than 85% of TBIs are classified as “mild” (MTBI), whose radiologic findings are minimal, if any, and do not correspond to clinical symptoms; consequently, it is suspected that many more victims do not seek medical attention or are seen at their doctor’s office. … more »

Brain

Voxel-Based Analysis of Diffusion Tensor Imaging in Mild Traumatic Brain Injury in Adolescents

Zili David Chu

Zili David Chu

Traumatic brain injuries (TBIs) and concussions are major causes of morbidity and disability in the United States and throughout the world. Disruption of white matter integrity is thought to contribute to persistent difficulties in cognitive, memory, and executive functions as well as emotional and somatic complaints. Up to now, a limited number of imaging techniques have been shown to … more »

Brain

Decreased Fractional Anisotropy Evaluated Using Tract-Based Spatial Statistics and Correlated with Cognitive Dysfunction in Patients with Mild Traumatic Brain Injury in the Chronic Stage

Tetsuya Wada

Tetsuya Wada

Yoshitaka Asano

Yoshitaka Asano

Approximately 80% of nonfatal traumatic brain injuries (TBIs) are classified as mild. Although they occur often, the pathophysiological, neurophysiological, and neuropsychological mechanisms of mild TBI (MTBI) remain poorly understood. Clinically, TBI is associated with the cognitive disturbances that often cause problems in family, school, work, or other social settings. We have … more »

Brain

Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study

Matilde Inglese

Matilde Inglese

Very little is known about the mechanisms leading to brain damage and development of disabling physical, cognitive, and emotional symptoms after mild traumatic brain injury (MTBI). MTBI accounts for 90% of the new cases of head trauma diagnosed annually in the United States, with an annual incidence rate as high as 128/100,000.

We hypothesized that trauma-induced molecular mechanisms may trigger iron accumulation that, in turn, … more »

Brain

Cognitive Impairment in Mild Traumatic Brain Injury: A Longitudinal Diffusional Kurtosis and Perfusion Imaging Study

Elan Grossman

Elan Grossman

There is a crucial need to establish neuroimaging biomarkers in mild traumatic brain injury (MTBI) that can account for its organic origin and identify patients at risk of long-term or permanently disabling cognitive impairment. This paper is part of a larger body of research our group is conducting to address the matter using multiple advanced MRI techniques, some of which we … more »