August 2014

Introduction

Brain Atrophy in Multiple Sclerosis

Alex Rovira

Alex Rovira

Multiple sclerosis (MS) is a chronic, persistent inflammatory-demyelinating disease of the central nervous system (CNS), characterized pathologically by areas of inflammation, demyelination, axonal loss, and gliosis scattered throughout the CNS. The disease has a predilection for the optic nerves, brain stem, spinal cord, and cerebellar and … more »

Brain

Brain Volume and Diffusion Markers as Predictors of Disability and Short-Term Disease Evolution in Multiple Sclerosis

Philipp Sämann

Philipp Sämann

For patients with multiple sclerosis (MS), MRI has gained an essential role in treatment management. In particular, quantitative markers of neuroaxonal damage have emerged as long-term predictors of MS-related disability and as surrogate markers of immuno­modulatory efficacy.1 Exceeding a certain threshold of neuroaxonal pathology might accelerate … more »

Brain

Subcortical and Cortical Gray Matter Atrophy in a Large Sample of Patients with Clinically Isolated Syndrome and Early Relapsing-Remitting Multiple Sclerosis

Robert Zivadinov

Robert Zivadinov

There is a growing interest in studying the extent of cortical and subcortical deep gray matter pathology (SDGM) starting from the earliest clinical stages of multiple sclerosis (MS). The relationship between the appearance of white matter (WM) lesions and SDGM atrophy in patients with MS is not well-understood.  A … more »

Brain

Automated Determination of Brain Parenchymal Fraction in Multiple Sclerosis

Mattias Vågberg

Mattias Vågberg

The importance of brain atrophy in neurodegenerative disorders is well-known. Considering the example of multiple sclerosis (MS), brain atrophy has been shown to be a valuable biomarker both for prognostic considerations and for measuring treatment effect. Although determination of brain atrophy is widely used in research … more »