August 2014

Introduction

Brain Atrophy in Multiple Sclerosis

Alex Rovira

Alex Rovira

Multiple sclerosis (MS) is a chronic, persistent inflammatory-demyelinating disease of the central nervous system (CNS), characterized pathologically by areas of inflammation, demyelination, axonal loss, and gliosis scattered throughout the CNS. The disease has a predilection for the optic nerves, brain stem, spinal cord, and cerebellar and periventricular white matter, though cortical and subcortical … more »

Brain

Reliability of Longitudinal Brain Volume Loss Measurements between 2 Sites in Patients with Multiple Sclerosis: Comparison of 7 Quantification Techniques

Françoise Durand-Dubief

Françoise Durand-Dubief

The primary objective of our work was to study the loss of the overall brain volume, ie, brain atrophy, as a potential marker of neurodegeneration in patients with multiple sclerosis (MS). Our hypothesis was that overall brain atrophy, a possible index peculiar to each patient, would be predictive of long-term disability. This hypothesis … more »

Brain

Subcortical Deep Gray Matter Pathology in Patients with Multiple Sclerosis Is Associated with White Matter Lesion Burden and Atrophy but Not with Cortical Atrophy: A Diffusion Tensor MRI Study

Roberto Cappellani

Roberto Cappellani

Robert Zivadinov

Robert Zivadinov

Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system in young people. Conventional MRI is an important tool not only for determining the early diagnosis of MS but also for monitoring disease progression. However, pathology outside of the focal … more »

Pediatrics

Gray Matter Pathology in MS: A 3-Year Longitudinal Study in a Pediatric Population

calabrese.pic

Massimiliano Calabrese

Several studies pointed out that gray matter damage in multiple sclerosis (MS) is not a late phenomenon. It appears to start early in the disease course, sometimes already at clinical onset. However, because it is often impossible to date the biological/subclinical onset of MS, which in adult patients may precede its clinical onset by some … more »

Brain

Brain Volume and Diffusion Markers as Predictors of Disability and Short-Term Disease Evolution in Multiple Sclerosis

Philipp Sämann

Philipp Sämann

For patients with multiple sclerosis (MS), MRI has gained an essential role in treatment management. In particular, quantitative markers of neuroaxonal damage have emerged as long-term predictors of MS-related disability and as surrogate markers of immuno­modulatory efficacy.1 Exceeding a certain threshold of neuroaxonal pathology might accelerate a patient’s transition to secondary-progressive MS or … more »

Brain

Subcortical and Cortical Gray Matter Atrophy in a Large Sample of Patients with Clinically Isolated Syndrome and Early Relapsing-Remitting Multiple Sclerosis

Robert Zivadinov

Robert Zivadinov

There is a growing interest in studying the extent of cortical and subcortical deep gray matter pathology (SDGM) starting from the earliest clinical stages of multiple sclerosis (MS). The relationship between the appearance of white matter (WM) lesions and SDGM atrophy in patients with MS is not well-understood.  A number of independent studies have shown that … more »

Brain

Automated Determination of Brain Parenchymal Fraction in Multiple Sclerosis

Mattias Vågberg

Mattias Vågberg

The importance of brain atrophy in neurodegenerative disorders is well-known. Considering the example of multiple sclerosis (MS), brain atrophy has been shown to be a valuable biomarker both for prognostic considerations and for measuring treatment effect. Although determination of brain atrophy is widely used in research regarding MS, it has not yet found … more »