September 2014

Introduction

MR Perfusion in the Preoperative Grading of Gliomas

Lea Alhilali

Lea Alhilali

Gliomas constitute the most common primary brain neoplasms in adults and comprise a diverse spectrum of tumors, histologically ranging from low-grade, indolent neoplasms to high-grade, aggressive lesions. Accurate, prospective grading of primary cerebral gliomas is critical for therapeutic planning and determining prognosis. Unfortunately, histopathologic grading of these lesions, either by stereotactic biopsy or surgery, is not without error; stereotactic biopsy is … more »

Brain

Does MR Perfusion Imaging Impact Management Decisions for Patients with Brain Tumors? A Prospective Study

Annette Johnson

Annette Johnson

We chose to research this topic because it seemed like there had been quite a few papers suggesting that perfusion MR imaging characteristics are associated with glial tumor grade, and even that perfusion MR imaging findings can help predict recurrence and survival in patients with glial tumors. But we had not seen any studies of perfusion MR imaging as a clinical … more »

Brain

Predicting Grade of Cerebral Glioma Using Vascular-Space Occupancy MR Imaging

Hanzhang Lu

Hanzhang Lu

It is known that angiogenesis plays a major role in tumor progression and is an important indicator of tumor grade. Tumor angiogenesis has two important features that can be exploited for noninvasive imaging. One is that cerebral blood volume (CBV) in the angiogenic region is often elevated, as more blood vessels tend to occupy more space in the brain parenchyma. A … more »

Brain

Histogram Analysis versus Region of Interest Analysis of Dynamic Susceptibility Contrast Perfusion MR Imaging Data in the Grading of Cerebral Gliomas

Meng Law

Meng Law

Dynamic susceptibility contrast perfusion MR imaging has been extensively investigated in brain diseases because cerebral perfusion and, more recently, the brain oxygen extraction/consumption are affected in many neurological disorders ranging from gliomas to autoimmune/inflammatory diseases (eg, multiple sclerosis) to neurodegenerative diseases (eg, Alzheimher disease). We chose to determine if there were more optimal methods for characterization and quantitation of relative cerebral … more »

Brain

Glioma: Application of Histogram Analysis of Pharmacokinetic Parameters from T1-Weighted Dynamic Contrast-Enhanced MR Imaging to Tumor Grading

Seung Chai Jung

Seung Chai Jung

Seung Hong Choi

Seung Hong Choi

It is not popular in clinical practice for radiologists to perform analysis based on whole-lesion segmentation of brain lesions for interpretation and diagnosis on MRI. The same method would be better applied to glioma grading by using MR perfusion imaging. However, many investigators performed quantitative analyses only from … more »

Brain

Perfusion Imaging of Brain Tumors Using Arterial Spin-Labeling: Correlation with Histopathologic Vascular Density

Tomoyuki Noguchi

Tomoyuki Noguchi

Blood flow is an important physiological variable that reflects biological activity, and tends to reflect functional aspects of a particular tissue. Arterial spin-labeling MR imaging (ASL-MRI) is an innovative imaging sequence capable of mapping blood flow distribution without the use of a contrast agent, that is, noninvasively. Considering that, in recent years, the application of contrast agents has been strictly regulated, … more »

Brain

Perfusion Measurement in Brain Gliomas with Intravoxel Incoherent Motion MRI

Christian Federau

Christian Federau

Measuring brain perfusion with intravoxel incoherent motion (IVIM) MRI was first proposed over 25 years ago,1 but this idea did not translate at the time into any useful clinical application. We thought this might have been due to technical challenges, and that software and hardware improvement over the last two decades might have solved some of the issues. The method is based on … more »