January 2015

Brain

Automated Optimization of Subcortical Cerebral MR Imaging−Atlas Coregistration for Improved Postoperative Electrode Localization in Deep Brain Stimulation

Andreas Kupsch

Andreas Kupsch

When investigating deep brain stimulation (DBS)–surgery-related issues, the question of accurate identification of the location of the active electrodes is crucial and essential. Clearly, both success and occurrence of adverse events can only be optimized if the DBS team is able to precisely identify the  anatomic … more »

Brain

White Matter Alteration of the Cingulum in Parkinson Disease with and without Dementia: Evaluation by Diffusion Tensor Tract–Specific Analysis

Koji Kamagata

Koji Kamagata

Parkinson disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer disease.1 In PD, the primary pathologic changes involve loss of nigrostriatal dopaminergic neurons and the presence of Lewy bodies (α-synuclein–immunoreactive inclusions), with neuronal loss in numerous brain regions.2 To distinguish these pathophysiologic changes in … more »

Brain

Thalamic Projection Fiber Integrity in de novo Parkinson Disease

David E. Vaillancourt

David E. Vaillancourt

My lab is dedicated to understanding Parkinson disease (PD) and movement disorders, to improve patient care in the future. MRI has tremendous potential to provide improved diagnostics and tracking of PD progression, and we are committed to this endeavor.

The current findings are important because … more »