April 2015

Introduction

Quantitative Diffusion Imaging of the Cervical Spinal Cord

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Erin Simon Schwartz

While diffusion imaging of the brain parenchyma has been in widespread clinical use for nearly 20 years, use of diffusion tensor imaging of the spinal cord has been less enthusiastically embraced by the neuroradiology community. However, this technique can add valuable quantitative information to more standard imaging sequences in a variety of conditions affecting the spinal cord, particularly the cervical spinal cord, including … more »

Spine

Diffusion Tensor Imaging in Multiple Sclerosis: Assessment of Regional Differences in the Axial Plane within Normal-Appearing Cervical Spinal Cord

Meng Law

Meng Law

Diffusion tensor imaging of the brain and spine has been a hot topic for a number of years now. We chose to investigate DTI in the spinal cord because of the challenges of doing DTI in the cord, as well as the many potential clinical applications of DTI in multiple sclerosis, spinal cord tumors, degenerative myelopathy, HIV-related spinal cord changes, spinal … more »

Spine

Variation in Anisotropy and Diffusivity along the Medulla Oblongata and the Whole Spinal Cord in Adolescent Idiopathic Scoliosis: A Pilot Study Using Diffusion Tensor Imaging

Winnie Chu

Winnie Chu

Defend Wang

Defend Wang

This topic was chosen because our group has a long history of research interest in the etiopathogenesis of adolescent idiopathic scoliosis (AIS). In our previous work, which evaluated the morphologic aspect of the spinal cord in AIS using MRI, we found that patients with AIS had increased total vertebral column length, … more »

Spine

Pulse-Triggered DTI Sequence with Reduced FOV and Coronal Acquisition at 3T for the Assessment of the Cervical Spinal Cord in Patients with Myelitis

Jerome Hodel

Jerome Hodel

The main topic of our research group is to develop advanced MR techniques in the field of neurodegenerative and inflammatory diseases. Because clinical disability in patients with multiple sclerosis (MS) is directly dependent on spinal cord lesions, we thought that diffusion tensor imaging could be a useful tool for the evaluation of white matter integrity at the early stage. However, DTI … more »

Spine

Diffusion Tensor Imaging Correlates with the Clinical Assessment of Disease Severity in Cervical Spondylotic Myelopathy and Predicts Outcome following Surgery

Meng Law

Meng Law

Neck and back pain are very debilitating conditions that affect many in the normal aging process. Cervical spondylosis and myelopathy are difficult to treat because the therapeutic options include conservative management with pain medicine, physical therapy, and, in some cases, decompression surgery. The decision to consider surgery is currently dependent on the patient’s symptomatology, neurologic signs, and MRI findings, which include … more »

Peripheral Nervous System

Diffusivity Measurements Differentiate Benign from Malignant Lesions in Patients with Peripheral Neuropathy or Plexopathy

Cynthia Chin

One of the most important clinical dilemmas in peripheral nerve disease is distinguishing benign from malignant peripheral nerve conditions.

Most brachial plexopathies are attributable to postradiation changes, primary and metastatic lung cancer, or metastatic breast cancer. Common causes of lumbosacral plexopathy are primary and metastatic tumor (including cervical, endometrial, ovarian, prostate, testicular, and colorectal cancer) and postradiation changes. For patients with a history … more »