May 2015


Susceptibility-Weighted Imaging in the Evaluation of Cerebrovascular Hemodynamics

Guest Editor Carlos Zamora

Guest EditorCarlos Zamora

Susceptibility-weighted imaging (SWI) is a high-resolution, fully velocity-compensated gradient-echo MRI sequence that maximizes intrinsic contrast differences between tissues by virtue of their local magnetic properties. This technique exploits susceptibility information contained within phase acquisitions and merges such with magnitude data to generate a clinically usable set of images. Notably, the functional incorporation of phase data in a clinical … more »

Physics Review

Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Parts 1 and 2

Mark E. Haacke

E. Mark Haacke

The development of susceptibility-weighted imaging (SWI) began in the mid-1990s, just following the advent of blood oxygen saturation imaging. Our group had been involved in the early brain/vein debate, that the veins played the critical role in visualizing information on brain function,1 not diffusion. We set out to demonstrate this and in the process found ourselves creating very high-resolution … more »


Susceptibility-Weighted Imaging in Pediatric Arterial Ischemic Stroke: A Valuable Alternative for the Noninvasive Evaluation of Altered Cerebral Hemodynamics

Thangamadhan Bosemani

Thangamadhan Bosemani

Our research team has focused on the clinical applications of advanced neuroimaging techniques, such as susceptibility-weighted imaging (SWI) in the evaluation of pediatric neurologic disorders. SWI provides useful functional information about blood oxygenation levels in intracranial vessels. In pediatric arterial ischemic stroke (PAIS), SWI focusing on venous drainage can provide noninvasive information about the degree of brain perfusion. We evaluated the … more »


Imaging the Effects of Oxygen Saturation Changes in Voluntary Apnea and Hyperventilation on Susceptibility-Weighted Imaging


Yulin Ge

Over the last decade, susceptibility weighted imaging (SWI) has grown tremendously as a new clinical face in routine brain MRI in addition to T1- and T2-weighted imaging. It is particularly useful in detecting small intracranial hemorrhages and venous anomalies due to its increased sensitivity to higher susceptibility materials such as iron and deoxyhemoglobin 1.  Although SWI is often used for high-resolution MRI … more »


Susceptibility-Diffusion Mismatch Predicts Thrombolytic Outcomes: A Retrospective Cohort Study

Zhicai Chen

Zhicai Chen

JianZhong Sun

JianZhong Sun

Intravenous thrombolysis with recombinant tissue plasminogen activator is a proved treatment for acute ischemic stroke within 4.5 hours of symptom onset. The foundation of intravenous thrombolysis for ischemic stroke involves reperfusion of the ischemic penumbra and salvage of threatened but potentially viable brain tissue. Work on imaging of the penumbra and … more »