July-August 2015

Introduction

Fetal Neuroimaging

Guest Editor Thierry Huisman

Guest EditorThierry A.G.M. Huisman

Guest Editor Andrea Poretti

Guest EditorAndrea Poretti

In the last years, the significant and continuous development of fetal MR imaging has revolutionized the prenatal diagnosis of congenital and acquired brain anomalies.1,2 In the early nineties, most diagnostic fetal MRI sequences were time-consuming and, hence, highly susceptible to fetal motion. Images of diagnostic … more »

Pediatrics

Prevalence and Spectrum of In Utero Structural Brain Abnormalities in Fetuses with Complex Congenital Heart Disease

Catherine Limperopoulos

Catherine Limperopoulos

Over the past 2 decades, advances in surgical and critical care management of congenital heart disease (CHD) have markedly reduced mortality. However, brain injury remains a major impediment to high quality of life in survivors. Recently, a growing body of literature suggests that a substantial component of this neurologic morbidity may be prenatal in origin. We are investigating the onset, prevalence, … more »

Pediatrics

Diffusion-Weighted Imaging of the Cerebellum in the Fetus with Chiari II Malformation

Cristina Mignone

Cristina Mignone

We made an observation of an increased T2 signal of the cerebellum in fetuses with the Chiari Type II malformation and myelomeningocele, and wondered whether this reflected a real change in the diffusion properties of the cerebellum. Our article describes that we did indeed find a difference when comparing this group with normal fetuses, supporting the hypothesis that this malformation is associated with … more »

Pediatrics

Correlation of Prenatal and Postnatal MRI Findings in Schizencephaly

Arastoo Vossough

Arastoo Vossough

Schizencephaly is a relatively rare malformation of the central nervous system without an entirely clear etiology. Clinical manifestations are diverse but often include varying degrees of developmental delay, sensorimotor impairment, and seizures. The prognosis in children with schizencephaly depends on whether they have an open or closed schizencephalic cleft, unilaterality or bilaterality of the cleft(s), location of the cleft(s), and presence … more »

Pediatrics

Agenesis of the Corpus Callosum: An MR Imaging Analysis of Associated Abnormalities in the Fetus

Orit Glenn

Orit Glenn

MRI is increasingly used to evaluate the fetal brain in cases where an abnormality is detected by routine prenatal sonography and in cases where the fetus is at increased risk for abnormalities in brain development. As such, it allows us to diagnose brain abnormalities in utero that are often missed by prenatal ultrasound.

I chose to study agenesis of the corpus callosum … more »

Pediatrics

MR Spectroscopy of the Fetal Brain — Is it Possible Without Sedation?

Vanessa Berger-Kulemann

Vanessa Berger-Kulemann

1H MR spectroscopy (MRS) has been established as a useful adjunct tool for morphologic imaging of the brain to understand the pathophysiologic mechanisms of fetal brain injury. The intrinsic magnetic properties of the fetal brain are used to compile a spectrum that contains different signal peaks, based on identifiable metabolites. The composition of these metabolites may indicate abnormalities in fetal brain metabolism, … more »