September-October 2015

Introduction

Clinical Applications of Arterial Spin-Labeling

Guest Editor Karl-Olof Lovblad

Guest Editor Karl-Olof Lövblad

Arterial spin-labeling (ASL) is a technique that has been around for a number of years but which remained dormant until recent enthusiasm developed again about its use and, finally, acceptance came over the last few years. From the start it was, in theory, a revolution: obtaining perfusion images with MR … more »

Pediatrics

Arterial Spin-Labeled Perfusion of Pediatric Brain Tumors

Kristen W. Yeom

Kristen W. Yeom

Brain tumors are the most common solid neoplasm of childhood and also a leading cause of cancer deaths in children. Unfortunately, these pediatric tumors can look bizarre, with a buffet of pathology that can be quite daunting when we first encounter them. For example, it’s not unusual for a scary-looking tumor with lots … more »

Brain

Perfusion Deficits Detected by Arterial Spin-Labeling in Patients with TIA with Negative Diffusion and Vascular Imaging

Whitney B. Pope

Whitney B. Pope

“Imaging-negative” TIA presents an interesting clinical condundrum because although the patient’s symptoms are assigned to an underlying ischemic cause, there is no confirmatory evidence that that is truly the case. Previously, in collaboration with stroke investigators at UCLA, we had looked at the utility of arterial spin-labeling (ASL) in comparison to DSC imaging … more »

Brain

Quantitative Blood Flow Measurements in Gliomas Using Arterial Spin-Labeling at 3T: Intermodality Agreement and Inter- and Intraobserver Reproducibility Study

Toshinori Hirai

Toshinori Hirai

Perfusion MR imaging with arterial spin-labeling (ASL) is a method using magnetically labeled blood water protons as an endogenous tracer to allow visualization and measurement of perfusion. Over the last decade, this technique has been used to evaluate perfusion in various pathologic conditions. The usefulness of perfusion MR imaging with ASL for the assessment of brain tumor … more »

Pediatrics

Hydrocephalus Decreases Arterial Spin-Labeled Cerebral Perfusion

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Kristen W. Yeom

Hydrocephalus is a common neurosurgical condition that often requires radiologist input. Some cases are pretty straightforward. For example, a patient comes in with headaches or altered mental status with newly enlarged vents, periventricular edema, and has hemorrhage or a big tumor causing obstruction. Or, there might be prior comparison in a shunted patient that shows … more »

Pediatrics

Quantitative Cerebral Perfusion Imaging in Children and Young Adults with Moyamoya Disease: Comparison of Arterial Spin-Labeling–MRI and H2[15O]-PET

Robert Goetti

Robert Goetti

In children with Moyamoya disease, cerebral perfusion studies are essential for preoperative planning and postoperative follow-up after revascularization procedures. As these children often undergo repeat examinations, the potential cumulative radiation burden of nuclear medicine studies, DSA, and CT is considerable and should be minimized as far as reasonably achievable.

Nuclear medicine perfusion studies have been shown … more »