November-December 2015

Introduction

IgG4-Related Disease

Guest Editor Julie Bykowski, MD

Guest EditorJulie Bykowski, MD

The multisystem involvement of IgG4-related disease (IgG4-RD) has been identified only within the past 15 years,1,2 over a century since Mikulicz’s report3 of a man with swelling of the lacrimal, submandibular, and parotid glands. Pancreatitis and sialadenitis are the 2 most common manifestations of IgG4-RD; however infiltration and fibrosis/sclerosis have been … more »

Head & Neck

MR Imaging of IgG4-Related Disease in the Head and Neck and Brain

Keiko Toyoda, MD

Keiko Toyoda, MD

The concept of IgG4-related disease (IgG4-RD) was first proposed by Hamano1 in 2001, and Japanese investigators have subsequently continued to play a leading role in defining its clinical spectrum and diagnostic criteria. In 2001 and 2002, Hamano et al1,2 reported autoimmune pancreatitis (AIP) associated with increased serum IgG4 levels and characterized histologically by … more »

Case Report

Immunoglobulin G4−Related Sclerosing Disease Mimicking Invasive Tumor in the Nasal Cavity and Paranasal Sinuses

Tomoaki Sasaki, MD

Tomoaki Sasaki, MD

Our article about IgG4-related diseases (IgG4-RD) described a very rare presentation in the head and neck, resembling malignant tumor. Mass lesions in the nasal cavity and paranasal sinuses can present difficulty in differential diagnosis. Fortunately, imaging usually plays a more important role in the evaluation of invasion and clinical stage than confirming a … more »

Head & Neck

Orbital Lymphoproliferative Disorders (OLPDs): Value of MR Imaging for Differentiating Orbital Lymphoma from Benign OPLDs

Kyoko Haradome, MD

Kyoko Haradome, MD

Orbital lymphoproliferative disorders (OLPDs) frequently appear as an orbital mass lesion (24–49%) and comprise a wide spectrum of diseases ranging from benign to malignant conditions. The majority of malignant OLPDs are orbital lymphomas, particularly mucosa-associated lymphoid tissue (MALT) lymphoma. Other OLPDs comprise several benign, noninfectious, chronic inflammatory diseases, including IgG4-related ophthalmic disease, reactive … more »

Head & Neck

Immunoglobulin G4–Related Disease of the Orbit: Imaging Features in 27 Patients

Laurence J. Eckel, MD

Laurence J. Eckel, MD

I chose to research this topic because of close collaboration with the ophthalmology department and a desire to provide a better differential diagnosis when interpreting images of abnormal orbital findings on CT and MRI.  Radiographically, we were often not recognizing or suggesting the possibility of IgG4-related disease (IgG4-RD) of the orbit … more »