November-December 2015

Introduction

IgG4-Related Disease

Guest Editor Julie Bykowski, MD

Guest EditorJulie Bykowski, MD

The multisystem involvement of IgG4-related disease (IgG4-RD) has been identified only within the past 15 years,1,2 over a century since Mikulicz’s report3 of a man with swelling of the lacrimal, submandibular, and parotid glands. Pancreatitis and sialadenitis are the 2 most common manifestations of IgG4-RD; however infiltration and fibrosis/sclerosis … more »

Head & Neck

MR Imaging of IgG4-Related Disease in the Head and Neck and Brain

Keiko Toyoda, MD

Keiko Toyoda, MD

The concept of IgG4-related disease (IgG4-RD) was first proposed by Hamano1 in 2001, and Japanese investigators have subsequently continued to play a leading role in defining its clinical spectrum and diagnostic criteria. In 2001 and 2002, Hamano et al1,2 reported autoimmune pancreatitis (AIP) associated with increased serum IgG4 levels and characterized … more »

Case Report

Immunoglobulin G4−Related Sclerosing Disease Mimicking Invasive Tumor in the Nasal Cavity and Paranasal Sinuses

Tomoaki Sasaki, MD

Tomoaki Sasaki, MD

Our article about IgG4-related diseases (IgG4-RD) described a very rare presentation in the head and neck, resembling malignant tumor. Mass lesions in the nasal cavity and paranasal sinuses can present difficulty in differential diagnosis. Fortunately, imaging usually plays a more important role in the evaluation of invasion and clinical stage than … more »

Head & Neck

Orbital Lymphoproliferative Disorders (OLPDs): Value of MR Imaging for Differentiating Orbital Lymphoma from Benign OPLDs

Kyoko Haradome, MD

Kyoko Haradome, MD

Orbital lymphoproliferative disorders (OLPDs) frequently appear as an orbital mass lesion (24–49%) and comprise a wide spectrum of diseases ranging from benign to malignant conditions. The majority of malignant OLPDs are orbital lymphomas, particularly mucosa-associated lymphoid tissue (MALT) lymphoma. Other OLPDs comprise several benign, noninfectious, chronic inflammatory diseases, including IgG4-related ophthalmic … more »

Head & Neck

Immunoglobulin G4–Related Disease of the Orbit: Imaging Features in 27 Patients

Laurence J. Eckel, MD

Laurence J. Eckel, MD

I chose to research this topic because of close collaboration with the ophthalmology department and a desire to provide a better differential diagnosis when interpreting images of abnormal orbital findings on CT and MRI.  Radiographically, we were often not recognizing or suggesting the possibility of IgG4-related disease (IgG4-RD) of … more »