July-August 2016

Head & Neck

4D-CT for Preoperative Localization of Abnormal Parathyroid Glands in Patients with Hyperparathyroidism: Accuracy and Ability to Stratify Patients by Unilateral versus Bilateral Disease in Surgery-Naïve and Re-Exploration Patients

George J. Hunter

George J. Hunter

Hyperparathyroidism became unequivocally recognized and accepted as the cause of the debilitating bone disease osteitis fibrosa cystica circa 1925. It was at that time that Edward Churchill and Oliver Cope successfully removed a mediastinal parathyroid adenoma at the Massachusetts General Hospital in Boston (MGH). … more »

Head & Neck

Accuracy of 2-Phase Parathyroid CT for the Preoperative Localization of Parathyroid Adenomas in Primary Hyperparathyroidism

Brent Griffith

Brent Griffith

Primary hyperparathyroidism, a disorder caused by the presence of one or more hyperfunctioning parathyroid glands, is ideally treated by surgical removal of the hyperfunctional tissue. In the past, this required bilateral cervical exploration, but improvements in preoperative gland localization and intraoperative parathyroid hormone assays have led … more »

Head & Neck

Predictors of Multigland Disease in Primary Hyperparathyroidism: A Scoring System with 4D-CT Imaging and Biochemical Markers

Ali Sepahdari

Ali Sepahdari

Multiphasic multidetector parathyroid CT (“4D-CT”) is an increasingly popular tool for preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism. It is often used when other techniques fail, and is increasingly also being used as a first-line localization strategy.

The existing literature on 4D-CT has … more »

Head & Neck

Dynamic CT for Parathyroid Disease: Are Multiple Phases Necessary?

Prashant Raghavan

Prashant Raghavan

Primary hyperparathyroidism (HPT) is a fatal illness if left untreated. Surgical removal of the hyperfunctioning gland remains the only effective treatment available. Imaging plays a vital role in localizing one or more abnormal parathyroid glands for surgical planning. Traditionally, ultrasonography and technetium Tc99m sestamibi scintigraphy have … more »