March-April 2017

Introduction

Glioma Imaging in the Era of Antiangiogenic Therapy

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Nikdokht Farid

In the rapidly evolving landscape of postsurgical, postradiation therapeutic strategies for patients with glioblastoma (GBM), including cytotoxic chemotherapy, antiangiogenic therapy, and immune therapy, bevacizumab has been established as a primary therapeutic option for recurrent GBM1,2 and has also shown substantial promise in the setting of … more »

Brain

Early Biomarkers from Conventional and Delayed-Contrast MRI to Predict the Response to Bevacizumab in Recurrent High-Grade Gliomas

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Dianne Daniels

Our group has previously introduced delayed-contrast MR imaging for calculating treatment-response-assessment maps (TRAMs) in patients with brain tumors undergoing standard treatments, providing a clear separation between an active tumor and treatment effects.1,2 Following this application of the TRAMs methodology to aid patient management and decision-making … more »

Brain

Dynamic Susceptibility Contrast-Enhanced MR Perfusion Imaging in Assessing Recurrent Glioblastoma Response to Superselective Intra-Arterial Bevacizumab Therapy

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Ilhami Kovanlikaya

Glioblastoma (GBM) is the most common aggressive primary brain tumor. Despite an aggressive multimodal treatment approach that includes surgical resection and chemoradiation, median survival is limited to approximately 14 months.1

Until recently, there was no standard treatment for recurrent disease after combined chemotherapy and radiation treatment. … more »