July-August 2017


Advanced Imaging in Pediatric Neurodevelopment

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Mai-Lan Ho

Human neurodevelopment is an incredibly complex and incompletely understood process, with sequential events beginning in the embryonic/fetal period and continuing throughout infancy, childhood, and adolescence. Characteristic changes at each stage of life are reflected by progression through successive neurologic and psychosocial milestones. This coordinated maturation occurs despite rapid fluctuations in growth and … more »


Diffusional Kurtosis Imaging of the Developing Brain

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Sarah Milla

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Amir Paydar

In 2011, we began our investigation into the detection of microstructural changes that occur in both the white matter (WM) and gray matter (GM) of the developing pediatric brain using an MRI diffusion technique called diffusional kurtosis imaging (DKI). This technique … more »


Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood

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Nils Daniel Forkert

Children, especially within the first few years of development, experience rapid and considerable changes of the macro- and microstructure of the brain. These changes include rapid growth of the brain tissue, myelination patterns and white matter connectivity alterations, and cerebral blood flow changes. Although age-related alterations of the corresponding imaging biomarkers … more »


Microstructure of the Default Mode Network in Preterm Infants

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Duan Xu

The human brain develops at an incredible rate during the first several years of life. During this period, the brain is extremely plastic as it is vulnerable. My technical team complements the efforts of the clinical team led by Drs. Jim Barkovich and Donna Ferriero to leverage imaging in order to improve … more »