January-February 2018


Imaging Gray Matter Damage in Multiple Sclerosis

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Massimo Filippi

Over the past 3 decades, many pathologic and imaging studies1–4 have supported the notion that gray matter (GM) involvement is a critical feature in the progression of MS. Importantly, GM damage has been shown to be clinically relevant because it helps to explain some of … more »


Juxtacortical Lesions and Cortical Thinning in Multiple Sclerosis

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Deborah Pareto

We are very interested in investigating the relationship between MRI-derived biomarkers and clinical outcomes in MS, particularly early in the disease evolution, when an accurate prediction of long-term prognosis is crucial to better plan therapeutic interventions. Our final goal is to establish a more complete … more »


Cortical Perfusion Alteration in Normal-Appearing Gray Matter Is Most Sensitive to Disease Progression in Relapsing-Remitting Multiple Sclerosis


Parsa Hojjat

Gray matter involvement in MS has been demonstrated in numerous recent studies. However, because of the limited resolution of existing structural imaging techniques, widespread quantification of gray matter damage and the corresponding impact on cognition has been limited. Perfusion imaging has been shown to enable the … more »


Modeling the Relationship among Gray Matter Atrophy, Abnormalities in Connecting White Matter, and Cognitive Performance in Early Multiple Sclerosis

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Amy Kuceyeski

MS is a complicated disease that has a heterogeneous presentation and progression. We believe that quantitative methods, including machine learning, may allow researchers to shed light on the relationship among white matter lesions, gray matter atrophy, and cognitive/physical impairments over the course of the disease. … more »