Ashok Panigrahy
Over the last two decades there has been dramatic improvement in neonatal care, and now it is commonplace for high-risk neonates to survive well into adulthood. However, this dramatic impact on mortality is hampered by the fact that a substantial portion of survivors go on to develop neurosensory, neurocognitive, and neuropsychiatric disabilities, impacting their … more »
In this study we describe a new pattern of cerebral damage that may affect both preterm and at-term neonates with a history of neonatal distress or seizures in the first week of life. The main feature of this pattern is the involvement of deep medullary veins (DMV), small vessels that drain deep white matter.
In our patients, congested and thrombotic DMV appear on T1-, T2-, and susceptibility-weighted images as … more »
Sonia Lomeli Bonifacio
Advanced MRI techniques provide a window into the neonatal brain. They allow us to study the impact of a perinatal insult on brain microstructure and metabolism as well as the potential impact of neuroprotective strategies, such as hypothermia, for neonatal encephalopathy. Our findings suggest that neonates with encephalopathy who are treated with … more »
Pia Wintermark
Hypoxic-ischemic encephalopathy (HIE) is a serious brain injury due to birth asphyxia that causes significant mortality and long-term morbidity, including cerebral palsy, mental retardation, learning difficulties, and blindness. Therapeutic hypothermia is currently the only available treatment that may prevent brain injury, but a significant proportion of treated newborns still develop neurological sequelae.
Our data … more »
Malek Makki
After birth, neonates with dextrotransposition of the great artery (d-TGA) require cardiopulmonary bypass (CPB) surgery within the first week of life. Despite improving perioperative intensive care management with lowering overall mortality rate, morbidity remains high, especially regarding the neurodevelopmental outcome in psychomotor and cognitive abilities during long-term follow-up. Impairment of the central nervous … more »
Lisa Paquette
Jessica Wisnowski
Multiple prior studies of term neonates with congenital heart disease (CHD) have documented delayed brain maturation (both in utero and in the preoperative postnatal period), particularly in term infants with single ventricle physiology, further increasing their risk for injury … more »
Maria Escolar
Krabbe disease, also known as globoid-cell leukodystrophy, is a rare autosomal recessive disorder caused by deficiency of the lysosomal enzyme galactocerebrosidase (GALC), which is essential for normal catabolism of the principal lipid component of myelin. This is a very rare disorder, with an incidence of 1 in 100,000 live births. Most patients with … more »