Joshua Nickerson
Brain perfusion imaging using MR is not a new idea, and indeed, both gadolinium-based techniques and noncontrast methods have been well described in the radiology literature for decades. However, in discussion with colleagues, both in academia and in the private practice world, it is apparent that, currently, dynamic perfusion scanning has become part of … more »
Toshinori Hirai
We previously studied vascular supply of meningiomas with angio-CT. This experience led us to do new research work using MR regional perfusion imaging (RPI). When we applied RPI with selective labeling of the external carotid artery to a patient with meningioma, we happened to detect an interesting finding about vascular supply of the … more »
Julia Furtner
Arterial spin-labeling is an MRI technique that enables the quantitative determination of tissue blood flow values without the need to administer contrast agents, thus offering a noninvasive MRI perfusion sequence for the generation of cerebral perfusion maps. This method takes advantage of the fact that water protons of the arterial blood in the … more »
Jeffrey M. Pollock
I was fortunate to stumble into an ongoing research project by inadvertently ruining the first attempt at scanning a volunteer. I began my fellowship at Wake Forest in 2006 and took an interest in physiologic imaging of brain tumors, and I became interested in DTI, spectroscopy, and perfusion, beginning work on … more »
Joseph Maldjian
Arterial spin-labeling (ASL) perfusion MRI has been in development for over a decade.1–3 During much of this time it had remained predominantly a research tool. I was a neuroradiology fellow at the University of Pennsylvania when pioneering work in this area was being conducted by Drs. Detre and Alsop. They were developing the … more »
Thu Le
Greg Zaharchuk
We chose to study this topic after we started routine implementation of arterial spin-labeling (ASL) imaging on our clinical magnets. We noticed the obvious findings from large AVMs, but were surprised to see how well more subtle, smaller AVMs … more »
Jeffrey M. Pollock
After joining the arterial spin-labeling (ASL) research team at Wake Forest, we began to mine our perfusion database. In addition to the global cases of hyperperfusion, we identified several causes of regional hyperperfusion without any other radiographic abnormality on MRI. Occasionally we thought these might be artifacts, but after reviewing the … more »