Saeed Fakhran
The imaging of mild traumatic brain injury (MTBI), commonly referred to as concussion, is a maturing and expanding field, with novel imaging methods being used for both clinical evaluation of patients as well as in research. While initial concussion imaging was focused on excluding more serious pathology (eg, hemorrhage) in these patients, the field … more »
Pratik Mukherjee
Bruce McCandliss
DTI characterizes the microstructural properties of biologic tissues through measurements of the orientation-dependent diffusivity of water protons. This renders DTI particularly sensitive to human brain white matter pathology at microscopic spatial scales, because the longitudinal arrangement of the axolemma, microtubules, … more »
Oded Gonen
Traumatic brain injury (TBI) annually accounts for 1.6 million emergency department visits and hospitalizations in the United States.1 More than 85% of TBIs are classified as “mild” (MTBI), whose radiologic findings are minimal, if any, and do not correspond to clinical symptoms; consequently, it is suspected that many more victims do not seek medical … more »
Zili David Chu
Traumatic brain injuries (TBIs) and concussions are major causes of morbidity and disability in the United States and throughout the world. Disruption of white matter integrity is thought to contribute to persistent difficulties in cognitive, memory, and executive functions as well as emotional and somatic complaints. Up to now, a limited … more »
Tetsuya Wada
Yoshitaka Asano
Approximately 80% of nonfatal traumatic brain injuries (TBIs) are classified as mild. Although they occur often, the pathophysiological, neurophysiological, and neuropsychological mechanisms of mild TBI (MTBI) remain poorly understood. Clinically, TBI is associated with the cognitive disturbances that often … more »
Matilde Inglese
Very little is known about the mechanisms leading to brain damage and development of disabling physical, cognitive, and emotional symptoms after mild traumatic brain injury (MTBI). MTBI accounts for 90% of the new cases of head trauma diagnosed annually in the United States, with an annual incidence rate as high as 128/100,000.
We hypothesized that … more »
Elan Grossman
There is a crucial need to establish neuroimaging biomarkers in mild traumatic brain injury (MTBI) that can account for its organic origin and identify patients at risk of long-term or permanently disabling cognitive impairment. This paper is part of a larger body of research our group is conducting to address the matter using … more »