Lea Alhilali
Gliomas constitute the most common primary brain neoplasms in adults and comprise a diverse spectrum of tumors, histologically ranging from low-grade, indolent neoplasms to high-grade, aggressive lesions. Accurate, prospective grading of primary cerebral gliomas is critical for therapeutic planning and determining prognosis. Unfortunately, histopathologic grading of these lesions, either by stereotactic biopsy or surgery, … more »
Annette Johnson
We chose to research this topic because it seemed like there had been quite a few papers suggesting that perfusion MR imaging characteristics are associated with glial tumor grade, and even that perfusion MR imaging findings can help predict recurrence and survival in patients with glial tumors. But we had not seen any studies … more »
Hanzhang Lu
It is known that angiogenesis plays a major role in tumor progression and is an important indicator of tumor grade. Tumor angiogenesis has two important features that can be exploited for noninvasive imaging. One is that cerebral blood volume (CBV) in the angiogenic region is often elevated, as more blood vessels tend to … more »
Meng Law
Dynamic susceptibility contrast perfusion MR imaging has been extensively investigated in brain diseases because cerebral perfusion and, more recently, the brain oxygen extraction/consumption are affected in many neurological disorders ranging from gliomas to autoimmune/inflammatory diseases (eg, multiple sclerosis) to neurodegenerative diseases (eg, Alzheimher disease). We chose to determine if there were more optimal … more »
Seung Chai Jung
Seung Hong Choi
It is not popular in clinical practice for radiologists to perform analysis based on whole-lesion segmentation of brain lesions for interpretation and diagnosis on MRI. The same method would be better applied to glioma grading by … more »
Tomoyuki Noguchi
Blood flow is an important physiological variable that reflects biological activity, and tends to reflect functional aspects of a particular tissue. Arterial spin-labeling MR imaging (ASL-MRI) is an innovative imaging sequence capable of mapping blood flow distribution without the use of a contrast agent, that is, noninvasively. Considering that, in recent years, the … more »
Christian Federau
Measuring brain perfusion with intravoxel incoherent motion (IVIM) MRI was first proposed over 25 years ago,1 but this idea did not translate at the time into any useful clinical application. We thought this might have been due to technical challenges, and that software and hardware improvement over the last two decades might have solved some … more »