Guest EditorThierry A.G.M. Huisman
Guest EditorAndrea Poretti
In the last years, the significant and continuous development of fetal MR imaging has revolutionized the prenatal diagnosis of congenital and acquired brain anomalies.1,2 In the early nineties, most diagnostic fetal MRI sequences were time-consuming … more »
Catherine Limperopoulos
Over the past 2 decades, advances in surgical and critical care management of congenital heart disease (CHD) have markedly reduced mortality. However, brain injury remains a major impediment to high quality of life in survivors. Recently, a growing body of literature suggests that a substantial component of this neurologic morbidity may be prenatal … more »
Cristina Mignone
We made an observation of an increased T2 signal of the cerebellum in fetuses with the Chiari Type II malformation and myelomeningocele, and wondered whether this reflected a real change in the diffusion properties of the cerebellum. Our article describes that we did indeed find a difference when comparing this group with normal fetuses, supporting … more »
Arastoo Vossough
Schizencephaly is a relatively rare malformation of the central nervous system without an entirely clear etiology. Clinical manifestations are diverse but often include varying degrees of developmental delay, sensorimotor impairment, and seizures. The prognosis in children with schizencephaly depends on whether they have an open or closed schizencephalic cleft, unilaterality or bilaterality of … more »
Orit Glenn
MRI is increasingly used to evaluate the fetal brain in cases where an abnormality is detected by routine prenatal sonography and in cases where the fetus is at increased risk for abnormalities in brain development. As such, it allows us to diagnose brain abnormalities in utero that are often missed by prenatal ultrasound.
I … more »
Vanessa Berger-Kulemann
1H MR spectroscopy (MRS) has been established as a useful adjunct tool for morphologic imaging of the brain to understand the pathophysiologic mechanisms of fetal brain injury. The intrinsic magnetic properties of the fetal brain are used to compile a spectrum that contains different signal peaks, based on identifiable metabolites. The composition of these … more »