Guest EditorJulie Bykowski, MD
The multisystem involvement of IgG4-related disease (IgG4-RD) has been identified only within the past 15 years,1,2 over a century since Mikulicz’s report3 of a man with swelling of the lacrimal, submandibular, and parotid glands. Pancreatitis and sialadenitis are the 2 most common manifestations of IgG4-RD; however infiltration and fibrosis/sclerosis have … more »
Keiko Toyoda, MD
The concept of IgG4-related disease (IgG4-RD) was first proposed by Hamano1 in 2001, and Japanese investigators have subsequently continued to play a leading role in defining its clinical spectrum and diagnostic criteria. In 2001 and 2002, Hamano et al1,2 reported autoimmune pancreatitis (AIP) associated with increased serum IgG4 levels and characterized histologically … more »
Masaki Katsura, MD
Immunoglobulin G4 is the rarest of the 4 subclasses of serum IgG. Little attention had been paid to this minor component of IgG until Hamano et al1 found that patients with autoimmune pancreatitis (AIP) display high serum concentrations of IgG4. The same group also reported that pancreatic tissues in patients with … more »
Tomoaki Sasaki, MD
Our article about IgG4-related diseases (IgG4-RD) described a very rare presentation in the head and neck, resembling malignant tumor. Mass lesions in the nasal cavity and paranasal sinuses can present difficulty in differential diagnosis. Fortunately, imaging usually plays a more important role in the evaluation of invasion and clinical stage than … more »
Kyoko Haradome, MD
Orbital lymphoproliferative disorders (OLPDs) frequently appear as an orbital mass lesion (24–49%) and comprise a wide spectrum of diseases ranging from benign to malignant conditions. The majority of malignant OLPDs are orbital lymphomas, particularly mucosa-associated lymphoid tissue (MALT) lymphoma. Other OLPDs comprise several benign, noninfectious, chronic inflammatory diseases, including IgG4-related ophthalmic … more »
Laurence J. Eckel, MD
I chose to research this topic because of close collaboration with the ophthalmology department and a desire to provide a better differential diagnosis when interpreting images of abnormal orbital findings on CT and MRI. Radiographically, we were often not recognizing or suggesting the possibility of IgG4-related disease (IgG4-RD) of … more »