Guest Editor Hillary R. Kelly
Minimally invasive parathyroidectomy (MIP) has increasingly become the standard of care for surgical treatment of primary hyperparathyroidism over bilateral neck exploration, due decreased morbidity and costs, with similar rates of surgical cure.1–3 Precise and accurate preoperative localization is critical to the successful performance of MIP, and parathyroid imaging has gone … more »
George J. Hunter
Hyperparathyroidism became unequivocally recognized and accepted as the cause of the debilitating bone disease osteitis fibrosa cystica circa 1925. It was at that time that Edward Churchill and Oliver Cope successfully removed a mediastinal parathyroid adenoma at the Massachusetts General Hospital in Boston (MGH). Subsequently, parathyroid surgery slowly developed around the world. … more »
Jenny K. Hoang
When I first started performing 4D-CT at Duke in 2009, the literature on 4D-CT was mostly from the surgeons and in surgical journals. Other than descriptions on the enhancement pattern, there were no articles advising radiologists on other imaging findings of a parathyroid adenoma. After reading several 4D-CT studies, I noticed … more »
Brent Griffith
Primary hyperparathyroidism, a disorder caused by the presence of one or more hyperfunctioning parathyroid glands, is ideally treated by surgical removal of the hyperfunctional tissue. In the past, this required bilateral cervical exploration, but improvements in preoperative gland localization and intraoperative parathyroid hormone assays have led to increased use of minimally invasive, or … more »
Kambiz Nael
There has been a need for accurate preoperative localization of parathyroid adenomas (PTAs) to decrease size of surgical incisions and complication rates. While ultrasound and technetium Tc99m sestamibi scintigraphy have been used as first-line tools to localize PTA, these tests can often be inconclusive.
Therefore, 4D-CT has been established as an alternative cross-sectional imaging … more »
Ali Sepahdari
Multiphasic multidetector parathyroid CT (“4D-CT”) is an increasingly popular tool for preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism. It is often used when other techniques fail, and is increasingly also being used as a first-line localization strategy.
The existing literature on 4D-CT has documented and validated its advantages over scintigraphy … more »
Prashant Raghavan
Primary hyperparathyroidism (HPT) is a fatal illness if left untreated. Surgical removal of the hyperfunctioning gland remains the only effective treatment available. Imaging plays a vital role in localizing one or more abnormal parathyroid glands for surgical planning. Traditionally, ultrasonography and technetium Tc99m sestamibi scintigraphy have been employed in localizing abnormal parathyroid glands. … more »