Prof. François Nicoli
The story of the cerebral collateral circulation began a very long time ago, more than a century.1
As early as 1987, an angiographic study performed in patients with a subacute proximal MCA occlusion provided evidence of the clinical impact of the velocity of the retrograde collateral filling. Authors of this study found that if … more »
André Kemmling
Recent randomized trials have shown the efficacy of imaging-based patient selection in predicting benefit from thrombectomy after acute proximal occlusion in the anterior circulation. The underlying concept of imaging-based criteria rests on the assumption that a small irreversible infarct (core lesion) in relation to a large area of potentially treatable hypoperfused critical ischemia … more »
Ken Uchino
Treatment of acute ischemic stroke has focused on patient selection over the past 2 decades. After time from onset to treatment was shown to be the important outcome predictor in intravenous thrombolysis, other predictors of success in reperfusion therapy were investigated, in order improve patient selection beyond the standard timeframe (initially 3 hours … more »
María Hernández Pérez
Until recently, conventional angiography has been the only technique able to give information about the dynamic status of the intracranial vessels. Despite different CT and MR techniques that have been developed to assess the grade of collateral circulation after a cerebral arterial occlusion, we found that the great majority of these … more »
Prof. François Nicoli
“There are three principal cranial collateral pathways…. (including) pial anastomoses between and among the three major cerebral arteries. These collateral pathways exist awaiting demand, and enlarge as demand for flow rate and volume increases. It is our impression that (stroke) prognosis is related to the richness of demonstrable pathways.”
These sentences are quite … more »
Richard Aviv
Collateral status is recognized as fundamentally important in patient selection and outcome determination in acute stroke. Yet, there were until recently a paucity of larger studies examining its effect in the presence of recanalization and common complications in stroke therapy such as hemorrhagic transformation. We wanted to tease out these elements with the … more »