Daniel Chow
Approximately 4.3 million (1.8%) adults and 750,000 (1.0%) children in the United States have been diagnosed with epilepsy or other seizure disorders; approximately one-third have seizures refractory to medical therapies.1,2 MRI is essential for the assessment of these patients with medically refractory epilepsy, as it allows identification of structural abnormalities which, when resected, … more »
Massimo Caulo
We have been involved in presurgical brain mapping with task-evoked functional MRI (fMRI) since 2000, and we have observed that brain function reorganizes in different ways in the presence of a tumor or a vascular malformation placed in proximity to eloquent cortex or within a functional network. We were aware that our findings … more »
Rose Dawn Bharath
A majority of the resting-state functional MRI literature on epilepsy describes connectivity differences in patients with epilepsy compared with healthy controls. Some studies reported diffuse decreased connectivity, while others found regions with increased connectivity, and still others found both. The diversity of these results is beautifully brought out in the commentary … more »
Dewen Hu
Numerous studies indicate that neuropsychiatric disorders including epilepsy are associated with brain dysfunction at a large-scale network level. However, most of the previous mesial temporal lobe epilepsy (mTLE) studies have focused on the epileptogenic zone, and those analyses paying attention to regions outside the hippocampus mainly focused on structural brain imaging. So … more »
Wei Liao
Guangming Lu
Idiopathic generalized epilepsy (IGE) is a common subtype of epilepsy. The quality of life of patients with IGE could be dramatically affected by generalized spike-wave discharges (GSWDs), which manifest as abnormal EEG signals rapidly spreading to the … more »
Elysa Widjaja
Epilepsy is considered a disorder of large neural networks. There is considerable interest in examining the neural networks in patients with epilepsy. Functional connectivity and structural connectivity can be assessed using fMRI and diffusion tensor imaging, respectively. Resting-state networks refer to spatially segregated brain regions that exhibit spontaneous low-frequency fluctuations and may … more »