Massimo Filippi
Over the past 3 decades, many pathologic and imaging studies1–4 have supported the notion that gray matter (GM) involvement is a critical feature in the progression of MS. Importantly, GM damage has been shown to be clinically relevant because it helps to explain some of the clinical manifestations of MS, including cognitive impairment, … more »
Laura Jonkman
Although histologic sections of MS brains have shown extensive cortical pathology, visualizing these lesions with MRI has been challenging. A low signal-to-noise ratio due to lower myelin concentrations in cortical gray matter (compared with white matter) has contributed to this difficulty. In turn, initial studies with conventional sequences at standard (1.5T) field strength … more »
Deborah Pareto
We are very interested in investigating the relationship between MRI-derived biomarkers and clinical outcomes in MS, particularly early in the disease evolution, when an accurate prediction of long-term prognosis is crucial to better plan therapeutic interventions. Our final goal is to establish a more complete characterization of the patient’s stage and evolution … more »
Parsa Hojjat
Gray matter involvement in MS has been demonstrated in numerous recent studies. However, because of the limited resolution of existing structural imaging techniques, widespread quantification of gray matter damage and the corresponding impact on cognition has been limited. Perfusion imaging has been shown to enable the quantitative study of gray matter function through … more »
Amy Kuceyeski
MS is a complicated disease that has a heterogeneous presentation and progression. We believe that quantitative methods, including machine learning, may allow researchers to shed light on the relationship among white matter lesions, gray matter atrophy, and cognitive/physical impairments over the course of the disease. In our paper, we chose to use … more »
Andrea Burgetova
MRI markers reflecting iron concentration in deep gray matter (DGM), such as R2*/quantitative susceptibility mapping (QSM), correlate with clinical severity and to a fair degree predict the evolution of disability in MS.1 In addition to DGM deposits, iron accumulates in activated microglial cells in white matter lesions (WMLs), while the normal-appearing white … more »
Alan Wilman
We started studying MRI of deep gray matter in MS about 10 years ago. This branched out from our interest in phase susceptibility imaging of lesions in MS. Around that time, interest in the importance of gray matter injury in MS was growing, but most gray matter work focused on the cortical … more »