Chang Yueh Ho
Pediatric brain tumors are the number one cause of cancer-related deaths in children.
Childhood cancer is the leading cause of death beyond infancy due to disease in the United States, with leukemia as the most common cancer. From 1975 to 2013, 5-year survival rates for childhood cancer have improved from just over … more »
Sridhar Vajapeyam
Pediatric brain tumors are a unique group of heterogeneous tumors. MR imaging remains the modality of choice for diagnosis including tumor extent, tumor grade, treatment planning, and image-guided therapies. Physiologic characterization of the tumor related to MR permeability and diffusion characteristics (eg, cellularity) may be used for further evaluation.
In our previous work, we … more »
Kristen Yeom
We knew arterial spin-labeling (ASL) perfusion would be great for stroke, but we were even more excited to get it rolled out for kids. It was a match made in heaven—no IV pricks, no power injector, no veins bursting, and heck, no gadolinium—and this was before we even knew this thing sticks … more »
Mariam Aboian
Tremendous advances have been made in the genetic characterization and classification of adult brain tumors, but the classification of pediatric brain tumors with respect to their genetic characteristics has not been as well characterized. In the 2016 WHO Classification of Tumors of the Central Nervous System, a new class of brain tumors … more »
Rafael Ceschin
Developing the serial quantitative imaging pipeline used in this work was part of my master’s research project as a graduate student. At the time, the phase I immunotherapy trial in this cohort had just wrapped up, and it became apparent that the question of identifying pseudoprogression close to the time of occurrence … more »
Stephen Kralik
While experienced pediatric neuroradiologists can differentiate low-grade brain tumors from high-grade brain tumors in most patients, information obtained from MR perfusion techniques can improve accuracy in some patients whose imaging features are otherwise indeterminate. Pediatric primary brain tumors have diverse cellular origins that result in diverse imaging appearances and, consequently, challenges in … more »