Warning: Declaration of My_Walker::start_el(&$output, $item, $depth, $args) should be compatible with Walker_Nav_Menu::start_el(&$output, $data_object, $depth = 0, $args = NULL, $current_object_id = 0) in /home2/ajnrblog/public_html/ajnrdigest/wp-content/themes/ajnr/functions.php on line 258
November-December 2019 Archives - AJNR News Digest

November-December 2019

Introduction

Evidence for Gadolinium Retention in the Human Brain

Vahe Zohrabian

Gadolinium-based contrast agents (GBCAs) have traditionally been considered very safe. The incidence of life-threatening adverse reactions occurring within 24 hours of GBCA administration is extremely low. Nephrogenic systemic fibrosis, a rare clinical entity first described in 2006, has essentially been eradicated given changes in practice in the use of GBCAs in patients with renal insufficiency. … more »

ADULT BRAIN

Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis

Forslin picture

Yngve Forslin

Brain gadolinium retention has received notable attention since the first report in 2014.1,2 Several studies have confirmed measurable signal changes attributable to gadolinium retention after multiple administrations of linear gadolinium-based contrast agents (GBCAs). However, results regarding macrocyclic GBCAs are conflicting,3 and the key question remains whether gadolinium retention has any negative effects.

In our … more »

Patient Safety

Gadolinium Deposition in Deep Brain Structures: Relationship with Dose and Ionization of Linear Gadolinium-Based Contrast Agents

Kang picture

Heejun Kang

Use of a gadolinium-based contrast agent (GBCA) increases the diagnostic utility of MRI by allowing better visualization of the disease process. However, the use of GBCAs is not without risks. GBCAs have been associated with acute adverse reactions, as well as with a rare but serious condition called nephrogenic systemic fibrosis. In … more »

ADULT BRAIN

High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted MR Images: Comparison between Gadobutrol and Linear Gadolinium-Based Contrast Agents

Moser picture

Franklin G. Moser

Prior to the discovery of nephrogenic systemic fibrosis (NSF), the radiology community felt that gadolinium-based contrast agents were exceedingly safe and could be injected with impunity. NSF made it clear that we had to rethink the use of gadolinium-based contrast agents. With the initial publication of reports of gadolinium deposition in … more »

Pediatrics

T1 Signal Measurements in Pediatric Brain: Findings after Multiple Exposures to Gadobenate Dimeglumine for Imaging of Nonneurologic Disease

Schneider picture

Guenther Schneider

We chose to research this topic because there is a great deal of misunderstanding in the literature. The gadolinium (Gd) retention issue has conveniently been classified (by individuals and manufacturing companies) as a macrocyclic versus linear issue. With the memory of nephrogenic systemic fibrosis (NSF) still fresh, it was all too easy … more »