Marlene Baumann
Autoimmune encephalitis encompasses a range of antibody-mediated neuroinflammatory disorders, with the expansion and emergence of new entities since anti-N-methyl-D-aspartate receptor (anti-NMDAr) encephalitis, the first specific antibody-mediated form, described by Dalmau et al in 2007.1
Autoimmune encephalitis is increasingly recognized as an underlying cause of new acute or recent-onset altered mental status including diverse and profound … more »
Brendan P. Kelley
Autoimmune encephalitis (AE) is an increasingly recognized category of antibody-mediated CNS disease that can have a wide range of clinical manifestations based on the specific brain regions involved. While clinical AE phenotypes of limbic dysfunction and/or seizure were the first to be recognized, it is now understood that a growing list of pathologic … more »
Amy Kotsenas
We chose this research topic because we saw several patients with what we called at that time anti-voltage-gated potassium channel complex antibody (VGKC Ab)–related epilepsy.1 We had observed anecdotally that there were similar findings in these patients to other causes of limbic encephalitis, as well as to findings in patients with Creutzfeldt-Jakob disease.2 … more »
Yaou Liu
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis was not infrequent in our hospital; however, the MRI characteristic was not typical and the clinical outcomes after therapy were poor in some patients. Therefore, we tried to investigate the brain MRI characteristics of anti-NMDAR encephalitis and their associations with clinical outcome at a 2-year follow-up.
For our article, … more »
Elif Bulut
Brain lesions are frequent in pediatric-onset neuromyelitis optica spectrum disorder (NMOSD) and distinguishing the clinical picture from other acquired demyelinating syndromes, such as acute disseminated encephalomyelitis (ADEM), could be very challenging, especially in patients presenting with brain manifestations without optic neuritis or myelitis.1 NMOSD has a very different treatment approach compared with … more »
Brendan P. Kelley
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multiorgan involvement due to a number of different immunologic mechanisms. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a general term that encompasses any of the various neuropsychiatric manifestations of the disease. Autoantibodies against double-stranded DNA (dsDNA) are a hallmark of SLE, but … more »