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May-June 2020 Archives - AJNR News Digest

May-June 2020

Introduction

Imaging in Mild Cognitive Impairment and Dementia

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Hediyeh Baradaran

Dementia is an epidemic affecting over 35 million people worldwide, costing over $600 billion annually.1 Given the increasing prevalence and economic impact of mild cognitive impairment (MCI) and dementia, there have been intensified efforts in early identification and early intervention to improve treatment success.1 Neuroimaging can play a central role in the early diagnosis … more »

ADULT BRAIN

Are Linear Measurements of the Nucleus Basalis of Meynert Suitable as a Diagnostic Biomarker in Mild Cognitive Impairment and Alzheimer Disease?

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K.D. Jethwa

Alzheimer disease (AD) is a common progressive neurodegenerative disease characterized by cognitive impairment and behavioral and functional decline. The deposition of intracellular “tangles” of hyperphosphorylated tau protein is one of the key pathologic hallmarks of the disease. Abnormal tau deposition begins within the basal forebrain before progressing to involve the neocortex via corticocortical axonal … more »

ADULT BRAIN

Regional Cerebral Blood Flow in the Posterior Cingulate and Precuneus and the Entorhinal Cortical Atrophy Score Differentiate Mild Cognitive Impairment and Dementia Due to Alzheimer Disease

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Bejoy Thomas

We chose to research this topic because our institute is a national facility for treatment, training, and research for neurologic and cardiovascular diseases in India. We have a strong subspecialty program on dementia and allied disorders and an ongoing registry for the same.

ERICA is a recently described, simple imaging scoring system for grading … more »

ADULT BRAIN

Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline

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Ilkka K. Martikainen

The increasing prevalence of dementia causes a substantial burden on the health care system. The modification of risk factors in individuals at risk of cognitive decline could curb the dementia epidemic, as first shown by a Finnish intervention study to prevent cognitive decline and disability (FINGER).1 This study found that a multimodal … more »