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Decubitus CT Myelography for Detecting Subtle CSF Leaks in Spontaneous Intracranial Hypotension - AJNR News Digest
March-April 2020
Spine
Figure 3 from Kranz

Decubitus CT Myelography for Detecting Subtle CSF Leaks in Spontaneous Intracranial Hypotension

Kranz picture

Peter G. Kranz

The discovery of CSF venous fistulas (CVFs) as a cause of spontaneous intracranial hypotension (SIH) has had a profound impact on treatment.1 Patients with no visible epidural fluid leakage who were once thought to have slow-flow leaks are increasingly recognized as harboring CVFs. The diagnosis of CVF is important because these patients do not respond well to epidural blood patches and usually require surgery to cure.2,3

CVFs can be quite difficult to find in some patients, however. Once initial spine imaging is performed and found to show no epidural fluid, some authors advocate for digital subtraction myelography (DSM) performed in the decubitus position.4 This technique requires 2 procedures on subsequent days, both requiring general anesthesia. Alternative methods of identifying CVFs are therefore clearly desirable.

CT myelography is performed at some institutions as initial spine imaging and has the advantage of being capable of detecting both epidural fluid and CVFs.5 Improving CVF detection on CT myelography would obviate the need for subsequent DSM.

In this article, we report on our experience that simply turning a patient to the decubitus position greatly facilitated the diagnosis in some cases. This effect seems to be partly due to increased contrast density over a fistula site due to dependent layering of intrathecal contrast, but also seems to be due to gravitational effects that promote filling of the fistula in the decubitus position.

This technique entails a higher radiation dose because of repeated scanning, and further work needs to be done to determine which patients will benefit most from this technique and how sensitivity compares with other methods such as DSM.

Reliable detection of CVFs in SIH remains a challenge, but one that is absolutely necessary to solve in order to provide appropriate care for patients suffering from the debilitating symptoms of SIH.  Decubitus imaging represents an incremental step in that direction.

References

  1. Schievink WI, Moser FG, Maya MM. CSF-venous fistula in spontaneous intracranial hypotension. Neurology 2014;83:472–73, 10.1212/WNL.0000000000000639
  2. Kranz PG, Amrhein TJ, Gray L. CSF venous fistulas in spontaneous intracranial hypotension: imaging characteristics on dynamic and CT myelography. AJR Am J Roentgenol 2017;209:1360–66, 10.2214/AJR.17.18351
  3. Wang TY, Karikari IO, Amrhein TJ, et al. Clinical outcomes following surgical ligation of cerebrospinal fluid-venous fistula in patients with spontaneous intracranial hypotension: a prospective case series. Oper Neurosurg 2020;18:239–45, 10.1093/ons/opz134
  4. Schievink WI, Maya MM, Moser FG, et al. Lateral decubitus digital subtraction myelography to identify spinal CSF–venous fistulas in spontaneous intracranial hypotension. J Neurosurg Spine 2019;31:902–05, 10.3171/2019.6.SPINE19487
  5. Kranz PG, Amrhein TJ, Schievink WI, et al. The “hyperdense paraspinal vein” sign: a marker of CSF-venous fistula. AJNR Am J Neuroradiol 2016;37:1379–81, 10.3174/ajnr.A4682

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